Dr Clement Higginbotham
Director of MRI
Dr Clement Higginbotham has been an active researcher in the fields of controlled drug delivery, bio nanotechnology, tissue engineering and biomedical materials for the past eleven years and has in excess of 130 publications in peer reviewed journals and conference presentations in these fields. He is also an inventor on a patent on lubricious hydrophilic coatings for medical devices. He is currently Director of the Centre for Nanotechnology and Materials Research at Athlone Institute of Technology which currently boasts in excess of 30 researchers, carrying out research on polymer-based formulations and compounds used in invasive and non-invasive medical devices. Dr. Higginbotham has been awarded in excess of €4.1M in research funding and has graduated 27 PhD students and 2 MSc students. He is currently supervising 5 postdoctoral researchers, 4 PhD students and 6 MSc students.
Journal Publications
James E. Kennedy, Declan M. Devine, John G. Lyons, Luke M. Geever, Clement L. Higginbotham (2009) The synthesis and characterisation of grafted random styrene butadiene for biomedical applications Journal of Materials Science, In Press, DOI: 10.1007/s10853-008-3156-2
Thomas J. Smith, James E. Kennedy, Clement L. Higginbotham (2009) The rheological and thermal characteristics of freeze-thawed hydrogels containing hydrogen peroxide for potential wound healing applications Journal of the Mechanical Behaviour of Biomedical Materials, In Press, DOI: 10.1016/j.jmbbm.2008.10.003
Ernest Foy, Joseph B. Farrell, Clement L. Higginbotham (2009) Synthesis of linear aliphatic polycarbonate macroglycols using dimethylcarbonate Journal of Applied Polymer Science 111 (1), 5 January, 217-227
Luke M. Geever, Ciaran C. Cooney, John G. Lyons, James E. Kennedy, Michael J.D. Nugent, Sinead Devery, Clement L. Higginbotham (2008) Characterisation and controlled drug release from novel drug-loaded hydrogels European Journal of Pharmaceutics and Biopharmaceutics, 69 (3), 1147-1159
Luke M. Geever, Ciaran C. Cooney, Declan M. Devine, Sinead M. Devery, Michael JD Nugent, Clement L. Higginbotham (2008) Negative temperature sensitive hydrogels in controlled drug delivery Macromolecular Symposia, 266 (1), 53-58
John G. Lyons, Paul Blackie and Clement L. Higginbotham (2008) The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug delivery International Journal of Pharmaceutics, 351 (1-2), 3 March, 201-208
Clement L. Higginbotham and James E. Kennedy (2007) Nanomedicine at Athlone Institute of Technology The Irish Scientist, 15, 45
Luke M. Geever, Michael J. D. Nugent and Clement L. Higginbotham (2007) The effects of salts and pH buffered solutions on the phase transition temperature and swelling of thermoresponsive pseudogels based on N-isopropylacrylamide Journal of Materials Science, 42 (23), December, 9845-9854
Michael J. D. Nugent and Clement L. Higginbotham (2007) Preparation of a novel freeze thawed Poly (vinyl alcohol) composite hydrogel for drug delivery applications European Journal of Pharmaceutics and Biopharmaceutics, 67 (2), September, 377-386
Luke M. Geever, César M. Mínguez, Declan M. Devine, Michael J.D. Nugent, James E. Kennedy, John G. Lyons, Austin Hanley, Sinead Devery, Paul T. Tomkins, Clement L. Higginbotham (2007) The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamide Journal of Materials Science, 42 (12), 30 June, 4136-4148
John G. Lyons, Harshad Holehonnur, Declan M. Devine, James E. Kennedy, Luke M. Geever, Paul Blackie, Clement L. Higginbotham (2007) The incorporation of an organically modified layered silicate in monolithic matrices produced using hot melt extrusion Materials Chemistry and Physics, 103 (2-3), 15 June, 419-426
John G. Lyons, Mark P. Hallinan, James E. Kennedy, Declan M. Devine, Luke M. Geever, Paul Blackie, Clement L. Higginbotham (2007) Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion process International Journal of Pharmaceutics, 329 (1-2), 62-71
Clement L. Higginbotham, Breda Lynch and Paul Tomkins (2006) A materialistic world The Irish Scientist, 14, 45
Sinead Devery, Clement L. Higginbotham and Paul Tomkins (2006) Testing time for polymers at the Centre for Biopolymer and Biomolecular Research The Irish Scientist, 14, 44
Declan M. Devine, Sinead M. Devery, John G. Lyons, Luke M. Geever, James E. Kennedy, Clement L. Higginbotham (2006) Multifunctional polyvinylpyrrolidinone-polyacrylic acid copolymer hydrogels for biomedical applications International Journal of Pharmaceutics, 326 (1-2), 50-59
Luke M. Geever, Declan M. Devine, Michael J.D. Nugent, James E. Kennedy, John G. Lyons, Austin Hanley, Clement L. Higginbotham (2006) Lower critical solution temperature control and swelling behaviour of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamide European Polymer Journal, 42 (10), 2540-2548
John G. Lyons, Declan M. Devine, James E. Kennedy, Luke M. Geever, Patrick O’ Sullivan and Clement L. Higginbotham (2006) The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion European Journal of Pharmaceutics and Biopharmaceutics, 64, 75-81
Michael J.D. Nugent and Clement L. Higginbotham (2006) Investigation of the influence of freeze-thaw processing on the properties of polyvinyl alcohol / polyacrylic acid complexes Journal of Materials Science, 41 (8), 2393-2404
Luke M. Geever, Declan M. Devine, Michael J.D. Nugent, James E. Kennedy, John G. Lyons and Clement L. Higginbotham (2006) The synthesis, characterisation, phase behaviour and swelling of temperature sensitive physically crosslinked poly (1-vinyl-2-pyrrolidinone)/poly(N-isopropylacrylamide) hydrogels European Polymer Journal, 42, 69-80
Michael J.D. Nugent, Austin Hanley, Paul T. Tomkins and Clement L. Higginbotham (2005) Investigation of a novel freeze-thaw process for the production of drug delivery hydrogels Journal of Materials Science: Materials in Medicine 16 (12), 1149-1158
Clement L. Higginbotham and Michael J.D. Nugent (2005) New generation smart materials at Athlone IT The Irish Scientist, 13, 49
Declan M. Devine and Clement L. Higginbotham (2005) The synthesis and characterization of chemically crosslinked N-vinylpyrrolidinone based hydrogels European Polymer Journal, 41 (6), 1272-1279
Declan M. Devine, Luke M. Geever and Clement L. Higginbotham (2005) Drug release from N-vinylpyrrolidinone / acrylic acid lubricious coatings Journal of Materials Science, 40 (13), 3429-3436
Michael J.D. Nugent and Clement L. Higginbotham (2004) Biomedical polymer research at AIT The Irish Scientist, 12, 55
Declan M. Devine and Clement L. Higginbotham (2003) The synthesis of a physically crosslinked NVP based hydrogel Polymer, 44, 7851- 7860
John S. Davies, Clement L. Higginbotham, E. John Tremeer, Charles Brown and Richard C. Threadgold (1992) Silyl derivatives as hydroxyl protecting groups in peptide synthesis and as lipophilic modifiers of peptides Journal of the Chemical Society, Perkins Transactions 1 3043
John A. Donnelly and Clement L. Higginbotham (1991) O-Heterocycles by the cyclisation of side-chain bromomethoxylated 2’-acetoxychalcones Monatshefte fur Chemie 122, 83
John A. Donnelly and Clement L. Higginbotham (1990) Flavone formation in the wheeler aurone synthesis Tetrahedron 46, 7219
Patents
Clement L. Higginbotham, Ray Hamilton, Ernest Foy, Guy Havet, John Cadogen (2008) Polymers produced from polyfunctional alcohols and processes for producing said polymers Patent Application No. EP 08155235.8
Anil Kumar, Peter C Foller, David Park, Declan M. Devine, C. W. M. Bastiaansen, J. P. Teunissen, Martin Cloonan, Clement L. Higginbotham (2007) Oriented polymeric sheets exhibiting dichroism and articles containing the same US Patent Publication Number US 2007/0291345 A1
Clement L. Higginbotham, Morgan Tierney, Finbar Dolan and Pat Hanley (2007) Coating for Biomedical Devices US Patent No.20070043160
Clement L. Higginbotham, Morgan Tierney, Finbar Dolan and Pat Hanley (2004) Coating for Biomedical Devices and Other Uses Patent application no. PA1365 IES, WO Patent 2004091685,
Michael J.D. Nugent, Clement L. Higginbotham (2008) Composite Gel-based Materials PCT/EP2008/052387 Filed on the 27th-February
Conference Publications
James E. Kennedy, John G. Lyons, Luke M. Geever, Clement L. Higginbotham (2008), Synthesis and characterisation of grafted co-polymers used as biomedical coatings, Society of Plastics Engineers, European Conference on Medical Polymers, September 2-4, Polymer processing and Medical Polymer Research Centres, Queen’s University Belfast, N. Ireland, pg 121-125
John G. Lyons, Mark Hallinan, Paul Blackie, Clement L. Higginbotham (2008), Sustained release polymeric matrices for oral drug delivery from a supercritical fluid assisted extrusion, Society of Plastics Engineers, European Conference on Medical Polymers, September 2-4, Polymer processing and Medical Polymer Research Centres, Queen’s University Belfast, N. Ireland, pg 127-131
Dominik Kirf, Sinead M. Devery, Neil J. Rowan, Clement L. Higginbotham (2008), Cyto- and geno- toxicological evaluation of multifunctional hydrogels for biomedical and drug delivery applications, Proceedings of the Ukems /NordEMS/MEG/IGG Joint Congress, June 15-18,University of Northumbria, Newcastle-Upon-Tyne, UK
James E. Kennedy and Clement L. Higginbotham (2008) Development of a novel drug eluting grafted thermoplastic elastomer for the prevention of restenosis Proceedings of the 8th World Biomaterials Congress, May 28-June 1, RAI Conference Centre, Amsterdam, Netherlands
Ciaran Cooney, Sinead M. Devery, Clement L. Higginbotham (2008) Biocompatibility of poly (N-isopropylacrylamide) copolymer hydrogels, Proceedings of the 8th World Biomaterials Congress, May 28-June 1, RAI Conference Centre, Amsterdam, Netherlands
Luke M. Geever, Michael J D Nugent, Clement L. Higginbotham (2008) Controlled Drug Delivery using Negative Temperature Sensitive Hydrogels Proceedings of the 8th World Biomaterials Congress, May 28-June 1, RAI Conference Centre, Amsterdam, Netherlands
Michael McGann, Michael J D Nugent, Clement L. Higginbotham (2008) Development of a polyvinyl alcohol cryogel for use as a drug delivery device Proceedings of the 8th World Biomaterials Congress, May 28-June 1, RAI Conference Centre, Amsterdam, Netherlands
Tommy J. Smith, James E. Kennedy, Clement L. Higginbotham (2008) Development of a hydrogel carrier for a H2O2 delivery system for chronic wounds Proceedings of the 8th World Biomaterials Congress, May 28-June 1, RAI Conference Centre, Amsterdam, Netherlands
Clement L. Higginbotham (2008), Research in the Polymer and Biomedical Area in AIT Proceedings of the 1st Annual Materials Ireland Conference, April 22-23, Hodson Bay Hotel, Athlone, Ireland
Oilbhe Lawlor, John G. Lyons, Sinead M. Devery, Clement L. Higginbotham (2008), Cytotoxicological evaluation of a novel nanoclay-filled polymer drug delivery vehicle Proceedings of the 1st Annual Materials Ireland Conference, April 22-23, Hodson Bay Hotel, Athlone, Ireland
Ernest Foy, Joe Farrell, Clement L. Higginbotham (2008) Polyurethane elastomers for soft tissue engineering applications using novel polycarbonate macroglycols Proceedings of the 1st Annual Materials Ireland Conference, April 22-23, Hodson Bay Hotel, Athlone, Ireland
James E. Kennedy, Clement L. Higginbotham (2008) Surface topography and drug elution characteristics of a grafted thermoplastic elastomer Proceedings of the 1st Annual Materials Ireland Conference, April 22-23, Hodson Bay Hotel, Athlone, Ireland
Luke Geever, Ciaran Cooney, Sinead M. Devery, Clement L. Higginbotham (2007), Negative temperature sensitive hydrogels in controlled drug delivery Proceedings of the International Congress on Biohydrogels, November 14-17, Congress Centre “Principe di Piemonte”, Viareggio, Italy
James E. Kennedy, Clement L. Higginbotham (2007), A Study of the Drug Release Mechanisms from a Grafted Thermoplastic Elastomer Proceedings of the International Congress on Biohydrogels, November 14-17, Congress Centre “Principe di Piemonte”, Viareggio, Italy
Michael J. D. Nugent, Clement L. Higginbotham (2007), Development of Novel Poly (Vinyl Alcohol) Composite Hydrogels for Biomedical Applications Proceedings of the International Congress on Biohydrogels, November 14-17, Congress Centre “Principe di Piemonte”, Viareggio, Italy
Ciaran Cooney, Luke Geever, Sinead Devery, Clement L. Higginbotham (2007), Biocompatibility of nanoporous N-isopropylacrylamide-N-(1-vinyl-2-pyrrolidone) copolymer hydrogels Proceedings of the Irish Society of Toxicology Conference Nanotechnology: implications for human health, the environment and food safety, 02 November, Dublin
Oilbhe Lawlor, John G. Lyons, Sinead M. Devery, Clement L. Higginbotham (2007), Cytotoxicological evaluation of a novel nanoclay-filled polymer drug delivery vehicle Proceedings of the Irish Society of Toxicology Conference Nanotechnology: implications for human health, the environment and food safety, 02 November, Dublin
James E. Kennedy, Clement L. Higginbotham (2007) Surface topography and drug elution characteristics of a grafted thermoplastic elastomer Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Luke Geever, Declan Devine, Michael Nugent, Clement L. Higginbotham (2007) Temperature sensitive poly (N-isopropylacrylamide) based gels for controlled drug delivery Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Ernest Foy, Joe Farrell, Clement L. Higginbotham (2007) Polyurethane elastomers for soft tissue engineering applications using novel polycarbonate macroglycols Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Declan Devine, John Lyons, Luke Geever, Clement L. Higginbotham (2007) Site specific delivery of aspirin to the small intestine Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Michael McGann, Clement L. Higginbotham, Michael Nugent, (2007) Development of novel hydrogels for drug delivery devices Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Oilbhe Lawlor, John Lyons, Sinead Devery, Clement L. Higginbotham (2007) Physical characterisation and toxicological evaluation of novel nanoclays filled polymer drug delivery vehicles Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Thomas Smith, James E. Kennedy, Clement L. Higginbotham (2007) Development of a hydrogel carrier for a hydrogen peroxide delivery system for chronic wound healing applications Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Ciaran Cooney, Luke Geever, Sinead Devery, Clement L. Higginbotham (2007) Cytocompatibility of N (1-vinyl-2-pyrrolidinone) based hydrogels Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Marta Carsi, Ricardo Diaz Calleja, Michael Nugent, Clement L. Higginbotham, Julio Guzman, Evaristo Riande (2007) Physicochemical characterisation of novel poly (2-ethoxyethylmethacrylate-co-2, 3 dihydroxypropylmethacrylate) membranes Proceedings of the 21st European Conference on Biomaterials, September 09 –13, Brighton, UK
Declan M. Devine, Luke M. Geever and Clement L. Higginbotham (2007) Development of hydrogels for moist wound healing Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
James E. Kennedy, Finbar B. Dolan and Clement L. Higginbotham (2007) Smart drug eluting delivery system for cardiovascular conditions using a grafted thermoplastic elastomer Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
Luke M. Geever, Declan M. Devine, Michael J. D. Nugent and Clement L. Higginbotham (2007) Controlled drug delivery using negative temperature sensitive hydrogels Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
Mark Hallinan, John G. Lyons, Paul Blackie and Clement L. Higginbotham (2007) Supercritical fluid assisted hot melt extrusion in the preparation of novel monolithic matrices for oral drug delivery Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
Oilbhe Lawlor, John G. Lyons, Sinead M. Devery and Clement L. Higginbotham (2007) Physical characterisation and toxicological evaluation of novel nanoclays filled polymer drug delivery vehicles Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
John G. Lyons, Declan M. Devine, Paul Blackie and Clement L. Higginbotham (2007) Supercritical fluid assisted hot melt extrusion for the production of monolithic matrices for oral drug delivery Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
Michael J. McGann, Michael J. Nugent and Clement L. Higginbotham (2007) Development of novel hydrogels for drug delivery devices Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
Ernest Foy and Clement L. Higginbotham (2007) Poly (carbonate urethane) elastomers as biostable polymers for tissue engineering applications Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
Thomas J. Smith, James E. Kennedy and Clement L. Higginbotham (2007) Development of a hydrogel carrier for a hydrogen peroxide delivery system for chronic wound healing applications Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
James E. Kennedy and Clement L. Higginbotham (2007) Swelling studies and surface topography of a grafted biomedical thermoplastic elastomer Proceedings of the 7th International Symposium on Frontiers in Biomedical polymers (FBPS 07), June 24 -27, Het Pand, Ghent, Belgium
John G. Lyons, Sinead M. Devery, Clement L. Higginbotham (2006) The influence of novel filler systems on hot melt extruded monolithic polymer drug delivery vehicles Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
Luke M. Geever, Declan M. Devine, James E. Kennedy, Sinead M. Devery, Oilbhe Lawlor, Clement L. Higginbotham (2006) Chemically crosslinked temperature sensitive hydrogels for controlled release drug delivery Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
Michael J. D. Nugent and Clement L. Higginbotham (2006) Development of novel cryogels for biomedical applications Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
Declan M. Devine, Luke M. Geever, Sinead M. Devery, Oilbhe Lawlor, and Clement L. Higginbotham (2006) Synthesis and characterization of hydrophilic polymers and their role in drug delivery Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
James E. Kennedy, Finbar B. Dolan, and Clement L. Higginbotham (2006) Spectral and mechanical characterization of potential drug eluting coatings for cardiovascular conditions Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
James E. Kennedy, Finbar B. Dolan, and Clement L. Higginbotham (2006) Investigation of the topography and swelling behaviour of UV polymerized thermoplastic elastomer (TPE) by the addition of various monomeric side groups for use as a stent drug eluting delivery system for cardiovascular conditions Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
Oilbhe Lawlor, Dominik Kirf, John G. Lyons, Sinead M. Devery, Clement L. Higginbotham (2006) Physical characterization and toxicological evaluation of novel nanoclay filled polymer drug delivery vehicles Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
Mark Hallinan, John G. Lyons, Paul Blackie, and Clement L. Higginbotham (2006) Supercritical fluid assisted hot melt extrusion in the preparation of novel monolithic matrices for oral drug delivery Proceedings of the 20th European Conference on Biomaterials, September 27 – October 01, Cite des Congres, Nantes, France
Declan M. Devine, Luke M. Geever, Sinead Devery and Clement L. Higginbotham (2006) In situ UV polymerization of a lubricious hydrophilic coating Proceedings of the International Conference on Advances in Biomaterials for Drug Delivery and Regenerative Medicine, page 124, 11-16 June, Hotel La Residenza, Capri, Italy
Luke M. Geever, Declan M. Devine, Sinead Devery, Oilbhe Lawlor and Clement L. Higginbotham (2006) Chemically crosslinked temperature sensitive hydrogels for site specific drug delivery Proceedings of the International Conference on Advances in Biomaterials for Drug Delivery and Regenerative Medicine, page 128, 11-16 June, Hotel La Residenza, Capri, Italy
John G. Lyons, James E. Kennedy, Sinead Devery and Clement L. Higginbotham (2006) The modification of monolithic devices prepared using hot melt extrusion with the use of novel filler systems Proceedings of the International Conference on Advances in Biomaterials for Drug Delivery and Regenerative Medicine, page 129, 11-16 June, Hotel La Residenza, Capri, Italy
Michael J. D. Nugent and Clement L. Higginbotham (2006) Development of novel cryogels for biomedical applications Proceedings of the International Conference on Advances in Biomaterials for Drug Delivery and Regenerative Medicine, page 165, 11-16 June, Hotel La Residenza, Capri, Italy
James E. Kennedy and Clement L. Higginbotham (2006) Grafted co-polymers for drug eluting applications Proceedings of the Materials Congress, April 5-7, Carlton House Terrace, London, UK
Declan M. Devine, Luke M. Geever, Sinead Devery and Clement L. Higginbotham (2006) The drug release and cytotoxicity response of hydrogels with potential for wound healing applications Proceedings of the Materials Congress, April 5-7, Carlton House Terrace, London, UK
Luke M. Geever, Declan M. Devine, Michael J. D. Nugent and Clement L. Higginbotham (2006) The synthesis, characterisation and drug release profile of temperature sensitive physically crosslinked N-isopropylacrylamide based hydrogels Proceedings of the Materials Congress, April 5-7, Carlton House Terrace, London, UK
John G. Lyons and Clement L. Higginbotham (2006) Novel oral matrix type drug delivery device prepared using conventional polymer processing techniques Proceedings of the Materials Congress, April 5-7, Carlton House Terrace, London, UK
James E. Kennedy, John G. Lyons, and Clement L. Higginbotham (2006) Investigation into the release rate of aspirin from grafted hydrophilic elastomer for use in drug eluting applications Proceedings of the Materials Congress, April 5-7, Carlton House Terrace, London, UK
James E. Kennedy and Clement L. Higginbotham (2006) Investigation of the topography and swelling behaviour of UV polymerised thermoplastic elastomers (TPE) by the addition of various monomeric side groups for use in smart biomedical applications Proceedings of the 1st International Conference on Materials, Energy and Design (MED 06), Page 89, March 14-17, Dublin Institute of Technology, Bolton Street, Dublin, Ireland
John G. Lyons and Clement L. Higginbotham (2006) Novel agar containing monolithic matrices for sustained oral drug delivery produced via hot melt extrusion Proceedings of the 1st International Conference on Materials, Energy and Design (MED 06), Page 86, March 14-17, Dublin Institute of Technology, Bolton Street, Dublin, Ireland
Luke M. Geever, Declan M. Devine and Clement L. Higginbotham (2006) Controlled erosion of physically crosslinked hydrogels for temperature dependent drug release Proceedings of the 1st International Conference on Materials, Energy and Design (MED 06), Page 88, March 14-17, Dublin Institute of Technology, Bolton Street, Dublin, Ireland
Michael J. D. Nugent and Clement L. Higginbotham (2006) Investigation of a novel bi layer polyvinyl alcohol and poly acrylic acid cryogel for use in wound dressing applications Proceedings of the 1st International Conference on Materials, Energy and Design (MED 06), Page 87, March 14-17, Dublin Institute of Technology, Bolton Street, Dublin, Ireland
Declan M. Devine, Luke M. Geever, Sinead Devery and Clement L. Higginbotham (2006) In situ UV polymerization of a lubricious polymer with potential for use as a medical device coating Proceedings of the 1st International Conference on Materials, Energy and Design (MED 06), Page 57, March 14-17, Dublin Institute of Technology, Bolton Street, Dublin, Ireland
John G. Lyons and Clement L. Higginbotham (2006) The use of filler materials in the preparation of monolithic polymer matrices for drug delivery Proceedings of the 3rd Annual BioNet Conference (The Biotechnology Showcase), page 63, January 18-19, Institute of Technology Tallaght, Dublin, Ireland
James E. Kennedy, Marco Schubert and Clement L. Higginbotham (2006) Synthesis and characterisation of grafted thermoplastic elastomers used in drug eluting applications Proceedings of the 3rd Annual BioNet Conference (The Biotechnology Showcase), page 59, January 18-19, Institute of Technology Tallaght, Dublin, Ireland
Declan M. Devine, Luke M. Geever and Clement L. Higginbotham (2006) Lubricious hydrophilic polymers for medical applications Proceedings of the 3rd Annual BioNet Conference (The Biotechnology Showcase), page 53, January 18-19, Institute of Technology Tallaght, Dublin, Ireland
Michael J. D. Nugent and Clement L. Higginbotham (2005) Investigation of a novel freeze-thaw process for the production of drug delivery hydrogels Proceedings of the 19th European Conference on Biomaterials, September 11 – 15, Sorrento Palace Hotel, Sorrento, Italy
Luke Geever, Declan M. Devine, Michael J.D. Nugent, and Clement L Higginbotham (2005) Physically crosslinked temperature sensitive hydrogels for controlled release drug delivery Proceedings of the 19th European Conference on Biomaterials, September 11 – 15, Sorrento Palace Hotel, Sorrento, Italy
Clement L. Higginbotham and Paul F. McDonald (2005) Evaluation of the properties of polycaprolactone blends for tissue engineering applications Proceedings of the 19th European Conference on Biomaterials, September 11 – 15, Sorrento Palace Hotel, Sorrento, Italy
Clement L. Higginbotham and Sean G. Lyons (2005) Development of a novel oral drug delivery device Proceedings of the 19th European Conference on Biomaterials, September 11 – 15, Sorrento Palace Hotel, Sorrento, Italy
Clement L. Higginbotham and James E. Kennedy (2005) Determination of the mechanical and thermal properties of Styrene Butadiene Styrene –g - N-isopropylacrylamide Proceedings of the 19th European Conference on Biomaterials, September 11 – 15, Sorrento Palace Hotel, Sorrento, Italy
Clement L. Higginbotham and James E. Kennedy (2005) Investigation into the use of styrene butadiene styrene – g – N vinyl 2 pyrrolidone for biomedical applications Proceedings of the 19th European Conference on Biomaterials, September 11 – 15, Sorrento Palace Hotel, Sorrento, Italy
Clement L. Higginbotham, Declan M. Devine and Luke M. Geever (2005) Lubricious hydrophilic polymers for drug delivery applications Proceedings of the 19th European Conference on Biomaterials, September 11 – 15, Sorrento Palace Hotel, Sorrento, Italy
Clement L. Higginbotham, Paul Blackie, Mark Hallinan, Sean Lyons and James Kennedy (2005) The use of supercritical fluid technology in the development of a novel oral matrix based drug delivery device formed using conventional plastics processing technologies Proceedings of the International Symposium on Supercritical Fluids, May 1-4, Rosen Centre Hotel, Orlando, Florida, USA Declan M. Devine, Luke Geever, Olivier Coubrun and Clement L. Higginbotham (2005) The synthesis and characterisation of a N-vinyl pyrrolidinone/ acrylic acid copolymer for drug delivery applications Proceedings of the Conference on Drug Delivery and Diffusion through Polymers, June 21, Institute of Physics, London, UK
James E. Kennedy, Jean-Marie Bocquel, Sean G. Lyons and Clement L. Higginbotham (2005) Determination of the Mechanical and Thermal properties of Styrene Butadiene Styrene -g - N-vinyl-2-pyrrolidone Proceedings of the Conference on Drug Delivery and Diffusion through Polymers, June 21, Institute of Physics, London, UK
Luke M. Geever, Declan M. Devine, Michael J.D Nugent and Clement L. Higginbotham (2005) The synthesis, characterisation and thermoreversible gelation of temperature sensitive physically crosslinked N-isopropylacrylamide based copolymers Proceedings of the Conference on Drug Delivery and Diffusion through Polymers, June 21, Institute of Physics, London, UK
P-A. Fourrier, J. E. Kennedy, K. Vaugh and C. L. Higginbotham (2005) Development of an arteriosclerosis model within ANSYSTM Proceedings of the 22nd International Manufacturing Conference, Challenges Facing Manufacturing, August 31st-September 2nd, Institute of Technology Tallaght, Dublin
Declan M. Devine, Luke Geever and Clement L Higginbotham (2004) Drug release from novel NVP/AA copolymer coatings for reduced friction applications Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
Declan M Devine, Luke Geever and Clement L. Higginbotham (2004) The synthesis and characterisation of crosslinked NVP/AA copolymers for medical applications Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
Clement L Higginbotham and Paul F. McDonald (2004) Evaluation of the properties of synthetic biodegradable polymer blends for tissue engineering applications Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
Michael J.D. Nugent and Clement L. Higginbotham (2004) Study of pH and temperature-sensitive polyvinylalcohol/ polyacrylic acid hydrogels Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
Clement L Higginbotham and James E. Kennedy (2004) Development of a polymeric drug eluting coating for biomedical applications Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
Clement L. Higginbotham and James E. Kennedy (2004) Determination of the mechanical and rheological properties of a polymeric drug eluting coating Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
John G. Lyons and Clement L. Higginbotham (2004) Development of a novel oral matrix type drug delivery device Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
Luke M. Geever, Declan M. Devine, Michael J.D. Nugent and Clement L. Higginbotham (2004) The synthesis, characterisation and swelling of temperature sensitive physically crosslinked N-isopropylacrylamide hydrogel copolymers Proceedings of the 10th International Conference on Polymers in Medicine and Surgery, September 6-8, Robinson College, Cambridge
Clement L. Higginbotham, Declan M. Devine, Luke M. Geever, James E. Kennedy, Paul F. McDonald, Sean J. G. Lyons and Michael J.D. Nugent (2004) Investigation of polymer systems for biomedical applications Nanofabrication Symposium, March 10-12, Dundalk.
Clement L. Higginbotham, Declan M. Devine, Luke Geever, James E. Kennedy, Paul F. McDonald, John G. Lyons and Michael J.D. Nugent (2004) Characterisation of polymer systems for drug delivery applications Nanofabrication Symposium, March 10-12, Dundalk.
Clement L. Higginbotham and James Kennedy (2004) Development of a novel multifunctional drug eluting coating Materials Congress, March 30-April 1, London
Declan M. Devine, Luke Geever and Clement L. Higginbotham (2004) The synthesis, characterisation and testing of a chemically cross-linked NVP/AA based copolymer for drug delivery applications Materials Congress, March 30-April 1, London
Declan M. Devine and Clement L. Higginbotham (2004) The synthesis, characterisation and swelling studies of a physically cross-linked NVP/AA based copolymer Materials Congress, March 30-April 1, London
Declan M. Devine, Luke Geever, Michael J. D. Nugent and Clement L. Higginbotham (2004) Synthesis, characterisation and swelling studies of a temperature sensitive NVP based copolymer for drug delivery applications Materials Congress, March 30-April 1, London
Michael J. D. Nugent and Clement L. Higginbotham (2004) Characterisation of pH and thermo-responsive polyvinylalcohol and polyacrylic acid blends using rotational rheometry Materials Congress, March 30-April 1, London
Clement L. Higginbotham and Paul McDonald (2004) Evaluation of the properties of biodegradable aliphatic polyester blends for tissue engineering applications Materials Congress, March 30-April 1, London
Sean G. Lyons, Liam J. Cawley, Alan P. Brazier and Clement L. Higginbotham (2004) Development of polymer-based compounds for novel oral drug delivery system Materials Congress, March 30-April 1, London
Declan M. Devine and Clement L. Higginbotham (2003) PVP based hydrogels for drug delivery applications Medical Device Technology, February 12-14, Birmingham
Declan Devine, Morgan Tierney and Clement L. Higginbotham (2002) Drug delivery from a novel polymeric coating Materials Congress, April 9-11, London
Clement L. Higginbotham, Michael Nugent and Jacqueline Corkish (2002) Synthesis and characterisation of novel polyelectrolytes Materials Congress, April 9-11, London
Donna E. Davies, Audrey Richter, Clement L. Higginbotham, Peter Alexandra and Ram P. Sharma (1992) Effect of hydrophobic substituents on the rate of formation of cyclic peptides using TGF-? residues 21-32 peptides Proceedings of the Twenty-Second European Peptide Symposium, September 13-19, Interlaken, Switzerland
Donna E. Davis, Clement L. Higginbotham, Audrey Richter, Peter Alexander and Nigel G. J. Richards (1991) The mechanism of interaction between TGF-alpha and the epidermal growth–factor receptor (EGF-R) Abstracts of Papers of the American Chemical Society, 201:72-MEDI Part 1 Apr 14
Donna E. Davies, Audrey Richter, J. Wayne Conlon, Clement L. Higginbotham, Michael E. Ward, Peter Alexandra and Nigel G. J. Richards (1991) EGF-receptor binding peptides from transforming growth factor ? (TGF-?): evidence for a multidomain interaction. Proceedings of the Twelfth American Peptide Symposium, June 16-21, Cambridge, Massachusetts, USA
